(USP26, DMF, Injectable Grade)
Paclitaxel is a natural product with antitumor activity. Natural Paclitaxel is extracted from Taxus yunnanensis and purified by HPLC method without any semi-synthesis process.
The chemical name for paclitaxel is (2aR,4S,4aS,6R,9S,11S,12S, 12aR,12bS)-1,2a,3,4,4a,6,9, 10,11,12,12a,12b-Dodecahydro- 4,6,9,11,12,-12b-hexahydroxy- 4a,8,13,13-tetramethyl- 7,11-methano-5H-cyclodeca [3,4]benz[1,2-b]oxet-5-one 6,12b-diacetate,12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3- phenylisoserine.
Paclitaxel is a white to off-white crystalline powder and is highly lipophilic, insoluble in water, and melts at around 216-217°C. It has a molecular weight of 853.93 and a molecular formula C47H51NO14 . Paclitaxel has the following structural formula:
Shelf life - 3 years.
* USP26 requires the sum of a1+a2 is no more than 0.5% .
BACKGROUND AND APPLICATIONS
Nature has provided many excellent medicines to benefit the human health. There are many effective anti-cancer agents in current use originally came from nature.
Paclitaxel may be one of the most important anticancer agents to be developed over the past two decades. Paclitaxel's anti-cancer activity was discovered in the 1960s during a large-scale plant-screening program sponsored by the National Cancer Institute (NCI). 35,000 plant species were screened for anticancer activity. An extract of the Yew Tree bark was found to have antitumor activity. That compound was named "Paclitaxel" or "Taxol".
With its unique mechanism of action as an inducer of tubulin assembly, paclitaxel has demonstrated impressive antitumor activity in patients with breast, lung (both non-small cell and small cell), head and neck, and advanced and platinum-refractory ovarian carcinomas.
Today Paclitaxel becomes one of
the major chemotherapy agents in cancer treatment.
packaged in a double-layer (plastic membrance - aluminum foil) bag and sealed in a aluminum tin .
Packaged in a double-layer (plastic membrane - alumimum foil) bag and sealed in a alumimum tin.
Storage: Store in original package between 2° and 25°C (36° to 77°F). Retain in the original tin to protect from light.
Handling and Disposal: Procedures for proper handling and disposal of anticancer drugs should be considered. Several guidelines on this subject have been published.1-7 There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate.
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